Marshall Horwitz Selected Research

Cyclic neutropenia

4/2004	Hereditary neutropenia: dogs explain human neutrophil elastase mutations.
1/2004	Paradoxical homozygous expression from heterozygotes and heterozygous expression from homozygotes as a consequence of transcriptional infidelity through a polyadenine tract in the AP3B1 gene responsible for canine cyclic neutropenia.
1/2004	Congenital and acquired neutropenia.
9/2003	Mutations associated with neutropenia in dogs and humans disrupt intracellular transport of neutrophil elastase.
1/2003	Role of neutrophil elastase in bone marrow failure syndromes: molecular genetic revival of the chalone hypothesis.
11/2002	Mice expressing a neutrophil elastase mutation derived from patients with severe congenital neutropenia have normal granulopoiesis.

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Marshall Horwitz Research Topics

Disease

8	Autosomal Recessive 3 Severe Congenital Neutropenia 04/2004 - 11/2002
6	Cyclic neutropenia 04/2004 - 11/2002
6	Neutropenia 04/2004 - 04/2003
5	Leukemia 01/2006 - 02/2002
3	Neoplasms (Cancer) 04/2005 - 01/2003
2	Carcinoma (Carcinomatosis) 04/2005 - 01/2003
2	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 11/2004 - 01/2004
1	Carcinogenesis 12/2005
1	Hematologic Neoplasms (Hematological Malignancy) 11/2004
1	Genetic Translocation (Chromosomal Translocation) 11/2004
1	Type 1 Diabetes Mellitus (Autoimmune Diabetes) 05/2003
1	Bone Marrow Failure Disorders 01/2003

Drug/Important Bio-Agent (IBA)

8	Leukocyte Elastase (Neutrophil Elastase)IBA 04/2004 - 11/2002
3	Proteins (Proteins, Gene)FDA Link 04/2004 - 02/2002
2	dl1520 (ONYX-015)IBA 04/2005 - 01/2003
2	Transcription Factors (Transcription Factor)IBA 11/2004 - 01/2004
2	Adaptor Protein Complex 3IBA 04/2004 - 09/2003
2	Peptide Hydrolases (Proteases)FDA Link 01/2004 - 09/2003
1	EnzymesIBA 01/2006
1	Oncogene Proteins (Oncogene Protein)IBA 12/2005
1	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 12/2005
1	Oxidoreductases (Dehydrogenase)IBA 11/2004
1	quinone (benzoquinone)IBA 11/2004
1	NAD (NADH)IBA 11/2004
1	Cadherins (E-Cadherin)IBA 11/2004
1	Core Binding Factors (Core-Binding Factor)IBA 11/2004
1	transcription factor NF-AT c3IBA 11/2004
1	core binding factor alphaIBA 01/2004
1	polyadenineIBA 01/2004
1	Pharmaceutical PreparationsIBA 01/2004
1	Notch ReceptorsIBA 01/2004
1	Serine Proteases (Serine Protease)IBA 01/2004
1	Insulin (Novolin)FDA Link 05/2003
1	Pancreatic Elastase (Elastase)IBA 04/2003

Therapy/Procedure

1	Intralesional Injections 01/2003
1	Therapeutics 01/2003